M T
What the F you just say?
NightStar
Gout is a type of arthritis and usually attacks a single joint suddenly and intensely, most commonly the first metatarsophalangeal (big toe).
Ivan L
Gout is a crystal arthropathy - it causes joint inflammation due to the deposition of urate crystals (related to uric acid in blood). It is well known that gout classically affects the joints in the big toe, particularly the base of the toe. It can also affect most other peripheral joints.
The reason for the big being the most often affected is two-fold - firstly, blood flow tends to pool in the feet in times of inactivity, and hence the clearance of uric acid can be reduced, leading to the higher propensity to crystallise. Secondly (and more importantly), crystallisation tends to happen in cooler areas of the body, and this joint is more prone to cooler temps than most others, hence gets affect by gout more than others.
Orignal From: Why does gout happen in the big toe? ?
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