Methlyprednisolone Side Effects Help?

Methlyprednisolone Side Effects Help?My grandfather is 73 years old and suddenly stopped taking methylprednisolone about two weeks ago. His doctor prescribed it for a sprained tendon. He is a prostate cancer survivor. He has diabetes, high blood pressure, gout and decreased kidney function. Since discontinuing the medication on day 2, he has suffered from loss of appetite, a ten pound drop in weight, stomach cramps and restlessness. He also takes Clonidine, Enalapril, Nadalol, Amlodipine, Hydralazine, Tekturna (for high blood pressure); Baby Aspirin; Glimperide and Januvia (for diabetes); Colchicine (periodically) for gout; Furosemide, Lipitor and Ferrous Sulfate (for cholesterol, I think). His doctor advised him to discontinue the Baby Aspirin. His stools have been dark, almost black for about two months prior to taking the methylprednisolone.

Pixie Chick
Your Grandfathers symptoms are not typical of Medrol use or withdrawal 100%. Generally with Medrol use increase appetite is present, with this in mind perhaps the discontinuation of the medication decreased his appetite, a ten pound weight loss in 2 days is very significant and worrisome though. Abrupt stopping of Medrol can cause nausea, vomiting, joint pain, muscle aches, fatigue, headache, fever. Use of Medrol does have side effects of restlessness, increased energy, euphoria, which resolves after discontinuing the medication. Medrol can cause irritation to the stomach and along with Aspirin can cause gastrointestinal bleeding. Black stools can be indicative of old blood, however your Grandfather is also taking an Iron Supplement that can turn stools black (Ferrous Sulfate). So as you see, there is a lot of mixed symptoms that are not necessarily related at this point to taking the Medrol Pak. What is concerning is the weight loss and abdominal cramping, concerning enough to be evaluated especially with his extensive medical history, they will also be able to verify the presence of blood in his stool vs the blackness being secondary to Iron replacement.

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