300mg every morning.
Sped
What makes you think allopurinol is losing its effectiveness? What is your serum uric acid (SUA) level? Are you checking it regularly?
I have been on 300 mg. allopurinol for 7 months, and if anything, it is more effective than ever. I test my SUA at least weekly, and it is now extremely low (<2.5 mg/dL), even when I drink beer.
Get a uric acid test kit and track your SUA. If it's consistently below 6 mg/dL you're OK, though <5 is better for recovering gouties.
Some people have been on allopurinol for decades, and I haven't seen any reports of it losing effectiveness over time. Bodies change, though, and sometimes the dosage must be adjusted. 300 mg. per day is the standard dose, but up to 800 mg. is permitted.
Keep track of your SUA and consult your doctor.
Hemen Ee
Allopurinol is an inhibitor that suppresses the degradation of purine to uric acid. Everyday, there are millions of body cell die off and the breaking down of the DNA structure produces huge amount purine. Part of these purines will be used by the body for the formation of new body cells while the rest of it will be sent to the liver to be further broken down to uric acid for disposal through urine.
When just started to take Allopurinol, the drug works fine in delivering the promised result, lower down your blood serum uric acid level. But the doctors forgot to tell you that this effect is only temporary.
Here is the flow of the purine disposal cycle, excess purines enter the liver to be degraded to uric acid, and the the uric acid is carried by the blood to the kidneys for disposal. There are 2 possible causes of hyperuricemia, the increased purine input or decreased uric acid output. If you have cut down or abstain from the high purine diet but your blood uric acid level still remains high, then the major cause of your gout is because of the weakened kidney function which results in the decrease of uric acid disposal capability.
Taking Allopurinol can only hold the un-degraded purine in the liver for certain period of time, eventually your body still have to get rid of the purine. If it cannot get rid of it through conversion to uric acid, it will force it to find some alternative channels such as through the skin to get rid of the unwanted purine, and that is why some gout patients experience skin rashes after they start taking Allopurinol.
And since the liver is holding up huge amount of purine, you CANNOT stop the consumption of Allopurinol, at least not suddenly stop it. This is because once the suppressing factor is removed, hell break loose! The liver is start churning out huge amount of uric acid and cause a serious spike of uric acid level that result in series of serious gout attack.
Sad but true, none of those gout drugs can remove the urate crystals that have already formed inside the gouty joints. As long as those tiny nasty crystals are still there, you will alway have chronic gout attack. You cannot depend on those chemical drugs for the rest of your life for those chemical residues will only further destroy your kidneys and send you to dialysis unit.
If conventional medicine works, you won't be suffering from the awful gout pain for years. It is time to give yourself a chance to try some alternative solution which makes more sense than the crazy pills.
Orignal From: Does the body become resistant to the benefits of Allopurinol over time?
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